Exercise, Heat, Cold & Other Stressors for Longevity | Lifespan with Dr. David Sinclair #3

This is so good thank you

This is golden information. Explained in the correct way (for me) by explaining the mechanisms in enough detail to get the gist of it, without making it too difficult (which in reality it probably is).

Hay me cuesta entender ... se inglés. Bueno tengo q repetir muchas veces 3l video...sí lo voy lograr

How is this about longevity the guy is a Norwood 7 with glasses.

doesnt reducing your calorie intake make you frail tho.

The part when he talks about their sponsor Athletic Greens 😂

You are my type of Professor, Dr and Scientist, I am 80 years old do not take medication, do yoga walk 10,000 or more steps a day and do some resistance exercises , I am up by 5 am. Have been a researcher for Holistic medicine ,Beauty and Longevity, for a long time, I am very happy to have found you, I will follow you as much as I can,🙏

Just wondering if holding one 's breathe for long periods is as beneficial as vigorous exercise? For example, we free dive (dive deep without air tanks) and training involves holding our breathe.

♾☮️♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️♥️

thankku guys great talk ....IM taking AEON suppliment.. its a game changer.. THANKS AGAIN DR SINCLAIR

What is the best way to track my age if I'm overseas and can't give blood?

I have a request: future research on aged folks like 60s,70s to 80+, my reasoning is that we ate living with some pathology and refuse meds offered since I just exercise the best I can. Thank you terrific video and more and more clarity from the lab and life styles.This is not the first video I have listened to with Dr S's research yet the added information here is so hopeful.

Correction: Dr. Sinclair mentioned that piriformis muscle went through that “hole”, that’s a mix up on his part. The piriformis attaches from the sacrum to the greater trochanter of the femur.

You are smart, but I know your weakness, you are bad at info commercials :) Thank you for informing us all. I love these podcast.

I devotedly started listening to this podcast ... i learned the right things... i am presently implementing low glycemic food, exercise, fasting in my daily regime. i dont feel tired or stressed .... i exercise daily for half an hour and vigrous exercise around e times a week... my focus increases... my brain fog gone...my memory enhanced...my organizational skill increases. this is what happens when you learn from right people. We genuinely thank you for sharing this valueble knowledge for free ..i am sure i will not get such knowledge even by sharing thousand of dollars anywhere in the world. Really thanks !!

It's better to eat during the day, which follows circadian rhythm and the fact that our digestion is stronger during AM and midday. I eat an early dinner and fast until 11 or so the next day.

David buy water filled dumbbells for traveling :)

I'm wondering if cold therapy works the same for every race

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late to the party but never the health. Thank you gentlemen :)

Thanks Dave. I appreciate you and your company MetroBiotec getting the FDA to ban NMN in the USA, so you guys can test it as a drug and line your pockets with millions of dollars, like you did with Resveratrol.

How does our blood glucose level work when we in a fastened state and we feel hungry? What is that hunger feeling? Because in other situations if we had to eat a high carb meal about 2hrs later we’ll get that glucose spike and be hungry again, but what does it mean if we’ve been in a fastened state?

Yeah baby!

You talk about HBOT therapy which is very effective but what are your thoughts on EWOT hiit exercise while breathing 93% oxygen, do you think this has merit?
Please don’t stop making the podcast!
Thanks

Can CKD BP THOIROID PERSON GO FOR HOT WATER THERAPY?

Heat has proven to increase growth hormone, which in turn has studies that point to a decrease in lifespan.

How much iron is too much? You need to define levels. Don’t just say low levels are best.

I'm a bit confused here Doc.

Pretty sure in the previous episode you said excess protein is not good. I was a bit gutted coz I enjoy resistance training (calesthenics + weights) and because of this maintain a high protein intake as part of my goals (previously building muscle now losing fat).
This episode you said weight training is beneficial but then how does that fit in with the required protein intake to build muscle and/ or strength?
Feels like we have to look at the overall picture of our health and trade off what is beneficial to us and what we enjoy/ what our preferences are.

If you could clarify this further please that would be super helpful.

Thanks
Sam

So many thought provoking tidbits but the hyperbaric chamber information...I've been screaming how beneficial it has to be for more than just wound therapy. Tried to get Medicare to pay for treating both my parents with it after strokes which seemed to be a no brainer but wasn't covered and I didn't have the funds at the time to cover it myself. Bringing hope to so many with all of this thought provoking data:) Thank you both.

Many CoViD19 patients were hypoxic and their health was amazing !!

What about people with thalassemia?

Does he bother mentioning intense excercise trigger mtor. As I stated before mtor is not bad or good. It's needed for life duh!?! It's just like blood glucose high chronic levels are what's bad. It's a wax and wane of the various biochem cascade that is needed. Short stimu,action followed by longer period of repair rinse wash repeat.

Got love when guest chose to hunt and peck information such as the effects of motor. HE starts BBAC are bad and MTOR is bad. Well guess what no MTOR then no muscle repair no muscle adaption i.e. getting stronger repairing tge damage from a workout. Mtor is needed. Now if he stated chronically elevated MTOR then yes. But no for these people it seems absolute.

Once they start the "everyone needs to become a vegetarian" I stop listening. We have been as humans eaten a primarily meat diet for countless millenia. It's what caused our increase in brain size and our reduction in gi system size. Just compare promagna to homo sapein. Or compare it to chimps or great apes. This is not gues work but proven with full support.

All the proof he is mentioning is from epidemiology studies. You can ne er form definitive conclusions off of these types of studies. Yet people love to use it for their goals. Rather than searching for truth they search to prove their theory2. That's not how science is suppose to work. It's the same with how big pharma has corrupted the research community as a whole.

Love you guys for such a priceless info!!! Beyond thankful 🙏 ❤

Great discussion. Also would be interested to know whether lean muscle and being slim is the ideal body type for health and longevity (So an Olympic athlete built (in general are lean and slim)/tennis player physique vs bodybuilder where we're mis-sold as being healthy and strong).

Also, given that low body fat and waist circumference levels is also ideal for longevity, what would be the ideal BMI to aim for in general. Any studies on whether those at a specific range of BMI live the longest and age gracefully into older years without chronic diseases? Just looking at other countries, cultures, and reviewing some studies, my thoughts are that the lower end of healthy weight range so between 18.5 to 22 or 23 is the ideal weight for longevity and too much muscle or body fat that exceeds out with this range will result in diminishing returns.

"I'll burn 10" was the best crazy line lol

I know and the ancient texts of the Torra also say so, that the nature in which we live was created in the laboratory thanks to the perfect mastery of the DNA of the Elohim. So extraterrestrials 25,000 years ago. Before 13.320 Later humans were created. We will do the same on another planet.
This is in Infinite Cycle in Time and Space. We will find the key to Eternal Life that is genetically engineered within us.
The time is ripe they are the SOURCE of all religions on earth, we must begin to understand and stop believing
Thanks to science we can
Rael movement
I'm a fan of David
I also have NMN , TMG , Ca-AKG, ect.It's certainly in the beginning
That will help us to understand more of what we are in order to help us live longer

I work out all the time.

So if David Sinclair lift weights every day almost how is he gonna build any muscle without protein? Even IF we don't need as much as gym bros will have us believe, we still need protein to build muscle it won't happen without it. Yet he said before he eats a low protein diet. Which would absolutely crash his recovery.

That makes me think. Because protein will increase mTOR but glucose that spikes inculin will ALSO increase mTOR. Yet the fact still remains. Protein is NEEDED to build muscle but it increases mTOR which is bad. So then what?

Another thing is that exercise in itself will activate mTOR. So too little mTOR is bad for us, and too much is terrible. So there needs to be periods of both. A balance of both that leads to healthy aging and no this is not a guess. It's a scientific fact.

So stressed cows and chickens that are all together in little space are mosmre healthy ? Becauee you want stressed food?

Great episode! How to get lower levels if hemoglobin if I live high in the mountains?

"believLBLE experience" yet no wif hof. same lipstick, dif lipstick here.

does taking athletic greens in the morning end a fast?

On the podcast with Andrew Huberman, you said that growth hormone actually ages the body. In this podcast you say that saunas are great for longevity. Now, it is also been found that sauna increases the body's growth hormone production by many folds. How are these two facts reconciled? Do saunas accelerate certain aspects of aging while slowing down other aspects of aging?

You mention taking AG1 every morning. Does this not break your fast?

Muy buen video. Gracias.

Why exactly hydrogen peroxide is bad? Because some people say it’s good and helpful. I am confused! 🤷🏼‍♀️🤷🏼‍♀️🤷🏼‍♀️🤷🏼‍♀️