eLife : Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas...

Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa. Michele LeRoux et al (2015), eLife http://dx.doi.org/10.7554/eLife.05701

The perception and response to cellular death is an important aspect of multicellular eukaryotic life. For example, damage-associated molecular patterns activate an inflammatory cascade that leads to removal of cellular debris and promotion of healing. We demonstrate that lysis of Pseudomonas aeruginosa cells triggers a program in the remaining population that confers fitness in interspecies co-culture. We find that this program, termed P. aeruginosa response to antagonism (PARA), involves rapid deployment of antibacterial factors and is mediated by the Gac/Rsm global regulatory pathway. Type VI secretion, and, unexpectedly, conjugative type IV secretion within competing bacteria, induce P. aeruginosa lysis and activate PARA, thus providing a mechanism for the enhanced capacity of P. aeruginosa to target bacteria that elaborate these factors. Our finding that bacteria sense damaged kin and respond via a widely distributed pathway to mount a complex response raises the possibility that danger sensing is an evolutionarily conserved process.

Good channel: https://www.youtube.com/Dlium
Subscribe, like and comment.

Good website: https://www.dlium.com
Bookmark, subscribe and comment.

Тэги:

#KeSimpulan #eLife #Pseudomonas_aeruginosa

Скачать видео