YouTube Ads Placement Targeting - Complete & Easy Guide on How to Place Ads on YouTube Channels

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Hello, please advise, I want to test in one Responsive Search Advertising company, where there are about 6 groups, pinning the Headline at position 2 (in each group) to measure the effectiveness.

Will it be more effective to do this through an Experiment with a 50/50 budget allocation, or in each group to make a duplicate of the advertisement and make a change?