Folic acid and birth defects

From our free online course, “Causal Diagrams: Draw Your Assumptions Before Your Conclusions”:
https://www.edx.org/course/causal-diagrams-draw-assumptions-harvardx-ph559x?utm_source=social&utm_medium=partner-marketing&utm_content=youtube-harvardx&utm_campaign=harvardx

Observational studies indicate that folic acid reduces the risk of birth defects. But the estimate changes depending on what the analysis adjusts for. How do we know which variables to include in our analysis to get the correct estimate?

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