Тиапридал при агрессии у пожилых.

4 года назад

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Канал Психфарм ТВ и д.м.н. М.Ю. Дробижев продолжают рассказ о тайнах Тиапридала. Этот препарат является нейролептиком. Но его используют не при шизофрении, а при агрессии у пожилых. Но почему пожилой человек становится агрессивным? И как ему может помочь Тиапридал? Смотрите выпуск Психфарм ТВ.
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Полезное чтение:

1: Lorke DE, Petroianu GA. Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review. J Appl Toxicol. 2019 Jan;39(1):101-116. doi: 10.1002/jat.3662. Epub 2018 Jul 19. Review. PubMed PMID: 30027640.

2: Ouyang X, Leonards PE, Tousova Z, Slobodnik J, de Boer J, Lamoree MH. Rapid Screening of Acetylcholinesterase Inhibitors by Effect-Directed Analysis Using LC × LC Fractionation, a High Throughput in Vitro Assay, and Parallel Identification by Time of Flight Mass Spectrometry. Anal Chem. 2016 Feb 16;88(4):2353-60. doi: 10.1021/acs.analchem.5b04311. Epub 2016 Jan 26. PubMed PMID: 26754356.

3: Lorke DE, Hasan MY, Nurulain SM, Shafiullah M, Kuča K, Petroianu GA. Acetylcholinesterase inhibitors as pretreatment before acute exposure to organophosphates: assessment using methyl-paraoxon. CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1052-60. PubMed PMID: 23244429.

4: Petroianu GA, Nurulain SM, Shafiullah M, Hasan MY, Kuča K, Lorke DE. Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon. J Appl Toxicol. 2013 Sep;33(9):894-900. doi: 10.1002/jat.2760. Epub 2012 May 19. PubMed PMID: 22611016.

5: Lorke DE, Hasan MY, Nurulain SM, Shafiullah M, Kuča K, Petroianu GA. Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors. J Appl Toxicol. 2011
Aug;31(6):515-23. doi: 10.1002/jat.1589. Epub 2010 Oct 27. PubMed PMID: 20981864.

6: Petroianu GA, Hasan MY, Nurulain SM, Arafat K, Sheen R, Nagelkerke N. Comparison of two pre-exposure treatment regimens in acute organophosphate (paraoxon) poisoning in rats: tiapride vs. pyridostigmine. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):235-40. Epub 2006 Sep 12. PubMed PMID: 17056080.

7: Petroianu GA, Hasan MY, Arafat K, Nurulain SM, Schmitt A. Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. J Appl Toxicol. 2005 Nov-Dec;25(6):562-7. PubMed PMID: 16193528.

8: Petroianu GA, Schmitt A, Arafat K, Hasan MY. Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride. Int J Toxicol. 2005 Mar-Apr;24(2):79-86. PubMed PMID: 16036766.

9: Petroianu GA, Hasan MY, Nurulain SM, Arafat K, Sheen R, Saleh A, Schmitt A. Protective drugs in acute large-dose exposure to organophosphates: a comparison of metoclopramide and tiapride with pralidoxime in rats. Anesth Analg. 2005 Feb;100(2):382-6. PubMed PMID: 15673862.
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