2-Minute Neuroscience: Nicotine

Nicotine saved me from long term Covid weakness and tiredness. I feel normal again. So far no cravings and unfortunately no decrease in appetite.

are nicotine receptors everywhere? like nicotine gets into the blood then binds into the receptors? how does it go from smoke to the brain

Watching this while I'm vaping

Went outside to smoke one of many cigarettes for the day, figured I better learn why I love this stuff so much.

Watching while sublingual use vape juice diluted in water and on zubsolv and caffeine

Can the brain undo those extra receptors or am I fucked for life, not being able to think or do anything when off nicotine?

Nicotine gum, CBD, Melatonine and vitamine D, Weed and natural herbs/supplements are the gifts from mother nature to destroy cancer and other diseases without being addicted to pharmaceutical dope. Bush doctor therapy! One love❤ We living in a concrete jungle!.

I smoked a cigarette while watching this. 🚬

I read that nicotine, somewhat enhanced by the low level radioactivity of tobacco activates once dormant vestigial neurons. Which is part of why nicotine addiction is so difficult to overcome. While most drugs act as agonists on existing neurons and other less potent agonists can used to satiate cravings, the neural receptors acted on by nicotine only respond to nicotine since the body no longer processes the natural agonists that act on those neurons.

I started using tobacco snus for a few months, each pouch had 50mg of nicotine in it, and I used about 8 a day. Thats 400mg, which is about 40 cigarettes a day.

I really enjoyed them and definitely prefer them to smoking, the burn sensation and the minty crystal taste which turned into a delicious tobacco taste. Stuffing one in the morning was fantastic and went really well with alcohol and tea/coffee. Stuffing one in the evening after eating was brilliant as well.


Since I live in The UK, it’s really hard to get and only this one shop sold them, which they ran out so I quit. Glad I did because I was getting sick of the increased heart rate (it’s a stimulant)

Its interesting to me how the withdrawal of nicotine can be compared to alcohol or benzodiazepine withdrawal because then the brain causes withdrawal due to the brain having to many GABA receptors.

I don't understand, if there's more nicotinic receptors the more they smoke, then as they smoke, over time they will receive a larger dopamine rush per smoke right? But the opposite happens. In reality, they get tolerance and get less dopamine per smoke.

2minutes brief lecturer in university about 20 minutes 😂😂😂
U are superhero (suparman😁❤️‍🔥)

My notes:
Nicotinic Acetylcholine receptors - throughout the whole NS
Nicotine - agonist, changes in the polarity of the receptor, increase in acetylcholine - enhanced cognition and attention, noradrenaline - stimulation and arousal
PNS - increase in sympathetic NS activity, secretion of catecholamines - adrenaline from adrenal glands
desensitize -> more receptors

How to cut without anabolics:

The thing is, its so addictive because it works so well for whatever situation that prompted it. Depression? Trauma? Breakup? Impossible task? Self medicating ADHD? It will help you, and will continue to do so for a few days, making EVERY situation better, good, bad doesn't matter. But then one day it doesn't.

It only works once.

But once is all it takes.

The horrible part is, since gene promotion/upregulation has brought about so many receptors, is that when an addict relapses, it is often stronger in effect.
Best case scenario: Your receptors in your stomach go top-fuel drag and give you an experience akin to that scene from the exorcist. You are now disgusted by the mere thought of nicotine, for now at least. You have a 30% chance of you actually stopping in response to this.

Worst: That narrow "theraputic" index is bullseyed, and it's bliss, even better than that first time, for about 30 mins. Finishing that assignment (You should really start it btw) is worse than whatever trauma started you on nicotine. You chase that same glorious buzz for the next 4 weeks until you repeat the cycle.

So this goes against what Dr. Ardis is saying and that nicotine can help people with long covid. More studies are definitely needed

Shouldn’t receptors eventually be downregulated because of too much signals?

Any trooth to Tucker's Nicatine frees your mind where as THC is basically the imperious curse from Harry Potter argument?

If I start a cupcake and the secret ingredient is nicotine. Do I have to disclose that information. Even though nicotine is not considered a controlled substances. I will put on the warning ⚠️ lable that the cupcakes are very addicting

I'm vaping on Cream Tobacco rn. Like this if you agree! 👍

Nicotine makes you shit like a maniac🤣

Anyone wonder why do we have nicotine receptors and why the body makes more after use. 😮wtf

What. It upregulates acetycholine? I didn't expect such a 'harmful' chemical to do that.

Thank you all i need to know

Nicotine is just weak. It doesn't give you euphoria or even elation. It just makes you woozy and then nothing else.

Dipping while watching this video

I wish I was rich. I would laugh the biggest most healthy product of food that will conquer the world like a storm. I just don't have the money. And all my people call me crazy. Grrr

I personally love nicotine

I thought nicotine was psychotropic not psychoactive

For all you npc’s out their be glad I use nicotine

Still didn't understand does the brain release nicotine ?

I don’t notice anything from nicotine except lightheadedness and nausea

Only drug that makes you smarter. Insane

I have never subscribed to a channel faster

literally the only video you can find that explains what nicotine actually does, as opposed to just 'smoking bad, don't do it'.

Good vid! Very factual. But I'm not smart enough to be able to use this info in a way that helps me decide if nicotine is harmful. My understanding (right or wrong) is that nicotine is comparable to caffeine as far as negative health effects. Anybody wanna comment?

Insteresting, but 2 minutes is not enough. I need MORE!

Finally, a video with actual information about nicotine and not a scare video to put kids in line

Nick a teen

watching this while buzzed

whos watching this while smoking nicotine

Can you do one on how to stop a friend from doing nicotine

Hello there. What exactly gets desensitized? Is it the receptors themselves, and in what way? Do they get thicker or something so the electricity becomes less intense? And how does this go in hand with there being more receptors?

Don’t really understand how it can be addictive, not THAT rewarding lol

Get your psychedelics products like DMT Vapes and powder, LSD, Psilocybin Bars and Shrooms from the name description above ..--:-

As someone who has used nicotine since they where 13 (and I was one of the first few in school who started that early, most didn't start until they where 17) this was rather informative and frankly I'd rather this be presented in school instead of what we got the whole time. I've made some bad choices and weed helped me get away from long-term nicotine use. That said nicotine is like caffeine for me

What's a good source of nicotine intake

I started nicotine (I don't smoke cigarettes) when I had a stressful week with my assistant manager. He was not qualified for the job and my boss chose to hire him after chatting with him at a bar.

I started using it so much and made me feel better for a bit. I am still doing it and it has been one ride.

Edit: I forgot the time frame it has been a year and a half since I started.

Yeeeee copenhagen extra long cut!