Fatty Acid Synthesis Pathway: Overview, Enzymes and Regulation

Wow

more than perfect

this was the best video I saw on this topic, very precise and comprehensible explanation!

hats off to u sir g
apka lec leny k baad mujhy ye topic sbsy easy lg raha hy

best video thank you

+ CO2 for acetyl coa carboxylase

Perfect explanation ❤

Saying that ChREBP is activated by "calories" is very misleading. ChREBP is a pure carbohydrate (glucose, fructose) sensing molecule.
So, for example, in the state of ketosis the cell have abundand "calories" available BUT it will not lead to FA synthesis.

In other words, it is primarily carbohydrates which makes one "fat"...

In highschool biology, we were only ever taught where sugars come from and how they're formed. I always wondered how fatty acids, as well as the other groups of organic molecules were formed, and now I know

Extremely helpful and simple. Thank you so much🥰🥰🥰🥰🥰

Finally understood the difference between hard work and smart work. You are just too smart 🤝

How 8 acetyl co A ?

What a wonderful video!

This video is very helpful! Thank you!

Amazing

Very understandable 👍.

This was great, simple to understand overview of fatty acid synthesis. Thanks so much!!

Plenty kisses for you. You just simplified the whole stuff.

thanks JJ Medicine. I've been really finding it difficult to understand the cycling reactions but after watching your video, I just understood. Thanks so much.

Not a student. Does the process always stop with a 16 carbon chain?, or can other smaller and/or larger chains also be made? If so, are certain enzymes regulators for determining the length?

Fatty acids. Yep

Saved a life, you made it straightforward and simple. Thanks

Keep the good work 🖤🖤

dude you rock

Just some to clarify some small inaccuracies for some people that may be confused:
-Before butyryl-CoA is formed it must undergo the reduction, dehydration and then reduction again whereas here it is shown that as soon as joining of Acetyl moiety to Melonyl-ACP takes place, the butyryl-Coa is formed.
-It also stays attached to ACP therefore it should actually be butyryl-ACP.
-The 6 carbon fatty acid is also produced on the second cycle not the first.
This is a great video tho and it helped me to fathom this process. To those, like me that are learning for undergrad study I recommend using a variety of sources and deeper research in general to help solidify this knowledge and to be able to apply it when answering questions.

Thank youuuuuu🤗

a couple of things to add for the sake of elaboration.

This palmitate can be elongated. by the addition of 2C units in the SER. Malonyl coA is still the 2C donor and NADPH provides reduction.

The brain is special in that it can produce very long chain fatty acids.


The resulting fatty acid can be desaturated in the SER by acyl coA desaturases (addition of cis double bonds). This is how unsaturated fatty acids are produced denovo!

This process requires, oxygen, NADH, cytochrome b5 and FAD linked reductase. First double bond normally added between the 9th and 10th C atom.



The fatty acid synthase has 6 enzymic domains.

1.Condensing enzyme (3-ketoacyl ACP synthase) domain onto which the initial acetyl coA is shifted from its original attachment to ACo domain (a non-enzymic domain)

2.malonyl/acetyl coA-ACP transacylase

3. 3 ketoacyl ACP reductase

4.3 hydroxy acyl ACP dehydratase

5.enoyl ACP reductase

Such an excellent video!

Keep going!! U're definitely awesome with fantastic diagrams thank you!!

Where is the CO2 in your net equation?

great video....will share it with my students...thanks !

Why it is necessary for fatty acid synthesis to complete 7 cycles?

In the formation of butyryl coA you haven't shown the formation of its keto acyl and skipped directly to the result i.e. reduction, dehydration and again reduction were not shown in the step for the preparation of butyryl coA

how does the -s goes away before having palmitate ?

Thank you

Thank you so much!I study in Turkey and I didn’t understand in the class but I get it now 👍🏻

Great video, but please increase the volume. Even with earphones at max volume i had to strain my ears.

Actually...actually...actually...actually

It's so great to not have an indian guy explain this stuf for a change.
Thank you, very cool!

very good video. nice explanation and not boring at all.thanks so much

Awesome

I'm a bit confused. Watched this as an overview before my exam as I don't have the time to go into details. You say the cycle goes 7 times with a butyryl-CoA as the template. The butyryl-CoA is made by combining an Acetyl-CoA and Malonyl-CoA giving off a CO2. Products from 7 cycles: 14 C added, 7 CO2, 7H2O, 7NADP+. You say we net 7CO2, but what about the one given off when we made Butyryl-CoA? Also, if the cycle goes 7 times, then we use 7 malonyl-CoA in the cycles alone plus 1 from making butyryl-CoA = 8? This is probably because I didn't read up on the finer details and is basing my knowledge on this video alone

This video is awesome..Thank you!

how are 14 NADPH formed with 2 per reduction reaction? arent there 2 reduction reactions in each cycle with 7 cycles total ?

كفو

thank you so much

thank you

THANK YOU THANK YOU THANK YOU

amazing! thanks for a million

Thanks..its awesome