ER resident proteins ( KDEL sequence)

Great! I finally understand now :D

How is the function of kkxx sequence different from kdel?

Nice video lecture brother...and one question... When these resident proteins are translocated into ER...then they remain bount to membrane or they are pulled down to the lumen of ER???

So, if the KDEL tag is supposed to signal confinement of a protein to the ER, then it must not be very efficient if there are conditions where you get inappropriate transfer out to the golgi. Are there measurements on how frequently the COP1 quality control mechanism has to operate, i.e. for any given ER resident protein, what is the likelihood that it's going to get shipped out "by mistake," and have to be returned via the COP1-dependent mechanism? Are there situations where such mistakes in targeting become more likely, e.g. ER stress, etc.?

Excellent service. Thank you for your efforts.

Thank you thank you thank you so so so much

Hi sir can u please suggest a better application to prepare good ppt slides like u have done which look amazing

Ph different That I know but which is more acidic Er or Golgi??? In which PH receptor dissociate

I have ADHD and the noise at the end of the video made it impossible for me to focus on your explanation. Anyways, keep up the good work!! And thanks for making me understand the process a little bit better :)

Hey isn't it cis Golgi that's facing towards the ER? So if in case some ER proteins go out of the ER they're in that space b/w ER and CIs Golgi right?
Or will it travel to the other side of the Golgi(trans-golgi) and does that protein gets recognised there?

What about KKXX ?

thanks man

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